For those looking to experience the best clubs in Cartagena, Fragma Club Cartagena is a top choice, offering an intimate setting with a capacity of up to 500. Mr Drink Liquor City is another popular venue, known for its vibrant nightlife and energetic crowd. Chiringuito Beach Club provides a unique experience with its beachside location and larger capacity, accommodating up to 1200 guests. Eivissa Cartagena is also a notable mention, offering a lively atmosphere and great music.

Cartagena boasts a rich musical heritage with several popular local musicians making waves in the industry. Manuel Medrano is a standout artist known for his soulful voice and captivating performances. Joe Arroyo, a legendary figure in Colombian music, continues to influence the local music scene. Mr Black El Presidente is another prominent artist, bringing a unique blend of urban and traditional sounds. Zaider and Luister La Voz are also well-loved musicians, contributing to the city's diverse musical landscape.

Outdoor live music in Cartagena can be enjoyed at several fantastic spots. Café del Mar Cartagena is a prime location, offering breathtaking sunset views along with live performances. The Centro de Convenciones Cartagena de Indias hosts various outdoor events, providing a larger space for music lovers. Chiringuito Beach Club combines the beauty of the beach with live music, creating a memorable experience. Plaza Majagua is another excellent spot, known for its vibrant atmosphere and live music events.