San Antonio's nightlife is bustling with top-notch clubs that cater to a variety of musical tastes. Lush Rooftop offers a chic atmosphere with stunning views and great music. Bonham Exchange is a historic club known for its diverse music and vibrant dance floors. The Rock Box is another excellent venue, hosting a range of live music events and club nights. For a more intimate setting, 502 Bar provides a cozy environment with a great selection of live music and DJ sets.

San Antonio is home to several popular local musicians who have made a significant impact on the music scene. Pepe Aguilar is a renowned artist known for his contributions to Latin music. Christopher Cross, a Grammy-winning singer-songwriter, has deep roots in the city. StaySolidRocky, a rising star in the hip-hop scene, also hails from San Antonio. Additionally, the rock band Nothing More has gained national recognition and continues to represent the city's vibrant music culture.

For outdoor live music, San Antonio offers several fantastic spots that combine great performances with beautiful settings. Six Flags Fiesta Texas is a popular destination that hosts a variety of live music events in an outdoor setting. The Arneson River Theatre, located along the picturesque River Walk, provides a unique venue for enjoying live music under the stars. Sunken Garden Theater is another excellent choice, offering a historic outdoor amphitheater with a range of live performances. Lastly, Hemisfair is a versatile outdoor space that frequently hosts live music events and festivals.