Prague's nightlife is renowned, and the city is home to some of the best clubs in the region. Club Roxy Prague stands out with its dynamic music scene and impressive lineup of DJs and live acts. Retro Music Hall is another top destination, known for its energetic atmosphere and diverse music genres. Duplex Prague offers a rooftop experience with stunning views of the city, making it a favorite among both locals and tourists. For those seeking a more underground vibe, Storm Club provides an eclectic mix of electronic music and a vibrant dance floor.

Prague is home to a number of popular local musicians who have made significant contributions to the music scene. Ben Cristovao is a well-known artist, blending pop and R&B influences in his music. Ektor, a prominent figure in the Czech rap scene, has a strong following with his impactful lyrics and performances. Mikolas Josef gained international recognition after representing the Czech Republic in the Eurovision Song Contest. Sofian Medjmedj is another rising star, known for his soulful voice and contemporary sound.

For outdoor live music, Prague offers several fantastic spots that combine great music with beautiful surroundings. Žluté lázně is a popular riverside venue that hosts a variety of outdoor concerts and festivals. Letiště Praha Letňany is another excellent location, often used for large-scale music events and festivals. The United Islands of Prague festival takes place across multiple outdoor venues in the city, offering a diverse range of performances. Lastly, the Metronome Festival is held at the Výstaviště Praha exhibition grounds, providing a spacious setting for enjoying live music under the open sky.