Lyon's nightlife is rich with top-notch clubs that cater to various musical tastes. Le Sucre stands out with its rooftop terrace and diverse electronic music events. Ninkasi, a well-known chain, offers multiple locations like Ninkasi Gerland and Ninkasi Cordeliers, each providing a lively atmosphere and great music. Terminal Club Lyon is another hotspot, renowned for its underground electronic music scene. Lastly, Le Petit Salon is a must-visit for those looking to experience cutting-edge DJ sets and live performances.

Lyon is home to several popular local musicians who have made significant impacts on the music scene. Gesaffelstein, known for his dark and atmospheric electronic music, hails from this vibrant city. Pomme, a talented singer-songwriter, has captivated audiences with her heartfelt lyrics and melodies. Jean-Michel Jarre, a pioneer in electronic music, also calls Lyon his home. Additionally, Sasso and Léman are rising stars, contributing to the city's rich musical tapestry.

For outdoor live music, Lyon offers some fantastic spots that combine great performances with beautiful settings. Les Nuits de Fourvière is a renowned festival held in the ancient Roman theaters, providing a magical backdrop for live music. Parc Sergent Blandan is another excellent venue, hosting various outdoor concerts and events. La Sucrière Lyon, located by the river, also offers outdoor spaces for live performances. Lastly, Theatres Romains De Fourviere is a historic site that frequently hosts large-scale outdoor concerts and festivals.