For those seeking the best clubs in San Nicolás de los Garza, La Comedia Show Live stands out as a top choice, offering a mix of live performances and entertainment. The city's nightlife is further enriched by venues like Teatro Nova, which hosts a variety of events and shows. Teatro de la Ciudad San Nicolás de los Garza is another excellent spot, providing a cultural touch to the club scene with its diverse programming. These venues collectively contribute to a dynamic and exciting nightlife experience in the city.

San Nicolás de los Garza is home to several popular local musicians who have made a significant impact on the music scene. Adan Zapata is a well-known figure, celebrated for his contributions to the regional music landscape. Los Tigrillos and Tropical Panamá are also highly regarded, bringing traditional and tropical sounds to the forefront. Fievre Looka and Priscila y Sus Balas De Plata add to the city's rich musical tapestry with their unique styles and performances. These artists collectively highlight the diverse and vibrant music culture of San Nicolás de los Garza.

For outdoor live music, San Nicolás de los Garza offers some fantastic spots that cater to different tastes. Estadio Universitario De Monterrey is a prime location for large-scale concerts and events, drawing massive crowds with its impressive capacity. Plaza La Joya also serves as a great venue for outdoor performances, providing a more intimate yet lively setting. These venues ensure that music enthusiasts can enjoy live performances under the open sky, adding a special charm to the city's music scene.