Itajaí is home to some of the best clubs in Brazil, offering a mix of electrifying music and vibrant nightlife. Warung Beach Club stands out as a premier destination, renowned for its top-tier electronic music events and stunning beachfront location. Belvedere Beach Club is another hotspot, attracting party-goers with its energetic atmosphere and impressive lineup of DJs. At HOME Itajai provides a more intimate clubbing experience, perfect for those who prefer a smaller venue. Cafe de La Musique Brava is also a must-visit, known for its chic ambiance and lively parties.

Itajaí has produced several popular local musicians who have made a significant impact on the music scene. Felipe Vilela is a standout artist, known for his captivating performances and unique sound. Dreysson Rodrigues is another talented musician, gaining popularity with his engaging style and musical versatility. Yeti Reggae Club brings a distinct reggae flavor to the local music scene, offering energetic and soulful performances that resonate with audiences.

For outdoor live music in Itajaí, there are several fantastic spots to enjoy performances under the open sky. Bailinho da Rebeska is a popular public venue that hosts lively outdoor events, creating a festive atmosphere. Centreventos Governador Luiz Henrique da Silveira is another excellent choice, offering a spacious setting for large-scale outdoor concerts. Additionally, the scenic beaches of Itajaí provide a picturesque backdrop for various outdoor music events, making it a perfect destination for music lovers.