For an unforgettable nightlife experience, Skopje offers some of the best clubs in the region. Stanica 26 is a top choice, known for its intimate setting and eclectic music selection. Sektor 909 is another popular venue, offering a vibrant atmosphere and a mix of electronic and dance music. Epicentar and The Loft are also well-regarded, providing a great mix of music genres and a lively crowd. For a larger venue, XL Summer Club offers a spacious dance floor and a variety of events.

Skopje is home to several popular local musicians who have made a significant impact on the music scene. Mesut Kurtis and Mevlan Kurtishi are well-known for their contributions to the local music culture. Adem Ramadani and Tuna are also prominent figures, each bringing their unique style to the stage. Slatkaristika and Adrian Gaxha are other notable artists, known for their engaging performances and musical talent.

When it comes to outdoor live music, Skopje has some fantastic spots to offer. Mladinski Kulturen Centar is a prominent venue that hosts a variety of outdoor concerts and events. Boris Trajkovski Sports Center is another excellent location, often featuring large-scale outdoor performances. For a more intimate setting, the Skopje Jazz Festival and Skopje Calling are popular events that take place in outdoor venues, providing a unique musical experience under the open sky.