La Plata is home to some of the best clubs where you can dance the night away. La Trastienda is a standout venue, offering a mix of live music and DJ sets in a spacious setting. Hogan's Club provides a more intimate clubbing experience with a variety of music genres. LIVE Club La Plata, espacio de arte is another great spot, known for its artistic vibe and energetic crowd. For a more laid-back clubbing experience, check out Casa Unclan.

La Plata has produced some of Argentina's most popular musicians. Patricio Rey y sus Redonditos de Ricota is a legendary rock band that originated from the city. Migrantes and El Mató A Un Policía Motorizado are also well-known local acts, each bringing their unique sound to the music scene. Other notable artists include Virus, a pioneering new wave band, and Facundo Cabral, a beloved folk singer.

For outdoor live music, La Plata offers several excellent spots. Estadio Atenas is a large venue that hosts major concerts and events, providing a fantastic atmosphere for live performances. Estadio Uno is another top choice, known for its impressive capacity and state-of-the-art facilities. Centro Cultural Estación Provincial often features outdoor music events in a more relaxed, cultural setting. Additionally, Centro Cultural Islas Malvinas is a great place to enjoy live music in an open-air environment.