Kassel's nightlife is diverse, with several clubs that cater to different tastes. Club Graf Karl is a well-known venue, offering a lively atmosphere and a variety of music genres. Frau Tanz is another top spot, known for its energetic dance floor and vibrant crowd. These clubs provide a great experience for anyone looking to enjoy a night out in Kassel.

Kassel is home to several popular local musicians who have made a significant impact on the music scene. Milky Chance, known for their unique blend of folk, rock, and electronic music, hails from this city. LEA, a talented singer-songwriter, has also gained widespread recognition. Other notable artists include AK and Jyll, who continue to contribute to Kassel's rich musical heritage.

For outdoor live music, Kassel has some fantastic spots that offer a great atmosphere. Auestadion Kassel is a prime location, capable of hosting large-scale events and concerts. The open-air setting provides a unique experience for music lovers. Additionally, the city's various parks and public spaces often host live music events, making it easy to enjoy performances in a relaxed, outdoor environment.