Guayaquil's nightlife is bustling with top-notch clubs that cater to diverse musical tastes. Corsario Salsa Guayaquil is a hotspot for salsa enthusiasts, offering energetic dance nights and live music. Vhuda is another popular club, known for its vibrant atmosphere and eclectic music selection. Discoteca Living Club provides a spacious venue with a dynamic mix of genres, perfect for a night out. For those looking for a more alternative scene, element-Alternativa and Tribal offer unique experiences with their distinctive music and ambiance.

Guayaquil is home to several renowned local musicians who have made significant contributions to the music scene. Julio Jaramillo, often referred to as 'El Ruiseñor de América,' is a legendary figure in Ecuadorian music. JohanN Vera has gained popularity with his contemporary pop sound and engaging performances. Ren Kai and Alex V are also notable artists, each bringing their unique style to the local music landscape. Additionally, AU-D and Gerardo have made their mark with their distinctive sounds and loyal fan bases.

For outdoor live music, Guayaquil offers some fantastic spots that combine great music with beautiful settings. Concha Acústica Parque Samanes is a popular venue, known for its open-air concerts and vibrant atmosphere. Estadio Modelo Alberto Spencer Herrera is another excellent location, hosting large-scale events and live performances. The Coliseo Voltaire Paladines Polo provides a spacious setting for outdoor concerts, attracting music lovers from all over the city. Additionally, the Centro de Convenciones de Guayaquil offers a versatile space for various outdoor music events, making it a go-to spot for live music enthusiasts.